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Explain to people with medication overuse headache that it is treated by withdrawing overused medication · advise people to stop taking all overused acute . Fluvoxamine has been observed to increase serum concentrations of mirtazapine, which is mainly metabolized by cyp1a2, cyp2d6, and cyp3a4, by threeto four-fold in humans. caution and adjustment of dosage as necessary are warranted when combining fluvoxamine and mirtazapine.
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